2-Chloro-4-fluoro-1-iodobenzene → (3-Chloro-4-iodophenyl)(methyl)sulfane

HRID 1694736Notes

Reaction equation

HRID 1694736 reaction equation
[CH3:1][S-:2].[Na+].F[C:5]1[CH:10]=[CH:9][C:8]([I:11])=[C:7]([Cl:12])[CH:6]=1>O>[Cl:12][C:7]1[CH:6]=[C:5]([S:2][CH3:1])[CH:10]=[CH:9][C:8]=1[I:11]

Participants

4

Reactant 2

HCID 27365592-Chloro-4-fluoro-1-iodobenzeneHCID 4378561Sodium methanethiolate

Product 1

HCID 67280544(3-Chloro-4-iodophenyl)(methyl)sulfane

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium methanethiolate (5 g) was added to a solution of 4-fluoro-2-chloro-iodobenzene (18.3 g) and stirred for 20 h. The mixture was poured into water, extracted with ether, washed with brine, dried (MgSO4) and evaporated. Yield 18.5 g.

Workup

  1. extractionextracted with ether
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-5b56f107b40b48fa941e904a89064b55
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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