HCID 67279732, compound → HCID 58297403, compound

HRID 1694738Notes

Reaction equation

HRID 1694738 reaction equation
[CH3:1][C:2]1([CH3:27])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=2[O:19]CC2C=CC=CC=2)[O:3]1>CCOC(C)=O.[Pd]>[CH3:7][C:6]1([CH3:8])[C:2]([CH3:1])([CH3:27])[O:3][B:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:16])[F:17])[CH:12]=[CH:11][C:10]=2[OH:19])[O:5]1

Participants

4

Reactant 1

HCID 67279732HCID 67279732, compound

Product 1

HCID 58297403HCID 58297403, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% Pd/C (0.5 g) was added to a solution of the product from step (i) in EtOAc (80 ml) and hydrogenated at RT and 1 bar for 1 h, and for a further 3 h at 3 bar. The catalyst was removed by filtration and the filtrate evaporated to leave a solid product. Yield 4.2 g.

Workup

  1. waitfor a further 3 h at 3 bar
  2. customThe catalyst was removed by filtration
  3. customthe filtrate evaporated
  4. customto leave a solid product

Sources & evidence

ORD record
ord-580baab62ba843799becd0156264d8b6
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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