(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid → HCID 11304172, compound

HRID 1694750Notes

Reaction equation

HRID 1694750 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[F:14].B([C:18]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:19]=1[O:20][C@@H:21]([CH3:25])[C:22]([OH:24])=[O:23])(O)O>C1COCC1>[Cl:30][C:28]1[CH:29]=[CH:18][C:19]([O:20][C@@H:21]([CH3:25])[C:22]([OH:24])=[O:23])=[C:26]([C:2]2[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=2[F:14])[CH:27]=1

Participants

4

Reactant 2

HCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67280622HCID 67280622, compound

Product 1

HCID 11304172HCID 11304172, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by the method of example 144 step (i) using the product from step (i), the product from example 151 step (iv) and THF as solvent.

Sources & evidence

ORD record
ord-633fe93bad1f424bbc721c3efd4c7359
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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