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HRID1694751

反应详情

EQUATION

反应方程式

HRID 1694751 的结构方程式

REACTANTS

反应物

3
反应SMILES：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

反应SMILES：O=S(=O)(c1ccc(Br)cc1)N1CCOCC1
HCID253128

4-(4-bromophenylsulfonyl)morpholine

C10H12BrNO3S

反应SMILES：C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
HCID67277298

未命名化合物

PRODUCTS

产物

1
反应SMILES：C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N2CCOCC2)cc1)C(=O)O
HCID11750653

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
反应SMILES：Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1
催化剂HCID178418228

Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)

C34H28Cl2FeP2Pd

反应SMILES：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A mixture of the product from example 151 step (iv) (0.126 g), sodium carbonate (0.22 g), 4-[(4-bromophenyl)sulfonyl]morpholine (0.16 g) and Pd(dppf)Cl2 (0.03 g) in dioxane (10 ml) was heated under reflux for 4 h. The mixture was evaporated and purified by RVHPLC (MeCN/aqNH4Cl). Yield 0.09 g.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 4 h
  3. customThe mixture was evaporated
  4. custompurified by RVHPLC (MeCN/aqNH4Cl)