HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 11750653, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-[(4-Bromobenzene)sulfonyl]morpholine | HCID 253128 | — |
| Reactant | (2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid | HCID 67277298 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 11750653 | HCID 11750653 | — |
Reaction Steps
A mixture of the product from example 151 step (iv) (0.126 g), sodium carbonate (0.22 g), 4-[(4-bromophenyl)sulfonyl]morpholine (0.16 g) and Pd(dppf)Cl2 (0.03 g) in dioxane (10 ml) was heated under reflux for 4 h. The mixture was evaporated and purified by RVHPLC (MeCN/aqNH4Cl). Yield 0.09 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158820B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-64016cd5b9d6432fadcad2baf1e5266c |
| Source note | uspto-grants-2012_04 |