HCID 178478049, compound → HCID 178420080, compound

HRID 1694808Notes

Reaction equation

HRID 1694808 reaction equation
Cl[C:2]1[C:3]([CH2:14][C:15]2[N:16]=[CH:17][NH:18][CH:19]=2)=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[C:4]1([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=[CH:2][C:3]=1[CH2:14][C:15]1[N:16]=[CH:17][NH:18][CH:19]=1

Participants

4

Reactant 1

HCID 178478049HCID 178478049, compound

Product 1

HCID 178420080HCID 178420080, compoundYield 57%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution of 50 mg (0.19 mmol) 4-(3-chloro-biphenyl-2-ylmethyl)-1H-imidazole in 40 ml methanol was added 40 mg of 10% palladium on charcoal and the mixture was then stirred for 16 h at room temperature under hydrogen at 0.6 bar excess pressure. The mixture was then filtered and the filtrate concentrated in vacuo to afford 25 mg (57%) of the title compound as a white crystalline solid. MS (ISP): 235.1 ([M+H]+).

Workup

  1. filtrationThe mixture was then filtered
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-6dd33e05b7eb4ba49a8fe83f69512f66
Source dataset
uspto-grants-2012_04
Patent number
US08158668B2

Reaction notes

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