HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 178510944, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-[4-(2-Amino-8-(3-(tert-butoxycarbonylamino)-propyl)-9H-purin-6-yloxymethyl)-benzyl]-2,2,2-trifluoro-acetamide | HCID 178453369 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178510944 | HCID 178510944 | 92% |
Reaction Steps
The tert-butoxycarbonyl derivative 11 (Example 23, 100 mg, 0.19 mmol) is suspended in 10 mL dichloromethane, and 2 mL trifluoroacetic acid are added. The mixture is stirred at room temperature for 30 min and poured into 70 mL of diethyl ether. The precipitate is collected by filtration and purified by flash column chromatography (CH2Cl2/MeOH 5:1) yielding 74 mg (0.17 mmol, 92%) of the title compound. MS (ESI) m/z 424.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163479B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ed13f9a25ae144c8878924616a09a422 |
| Source note | uspto-grants-2012_04 |