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HRID1695096

反应详情

EQUATION

反应方程式

HRID 1695096 的结构方程式

REACTANTS

反应物

2
结构：CN
HCID6329

Methylamine

CH5N

结构：CC(C)(C)OC(=O)NCCCc1nc2c(OCc3ccc(CNC(=O)C(F)(F)F)cc3)nc(N)nc2[nH]1
HCID178453369

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NCCCc1nc2c(OCc3ccc(CN)cc3)nc(N)nc2[nH]1
HCID178453368

未命名化合物

收率 94%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

Trifluoroacetamide 11 (Example 23, 100 mg, 0.19 mmol) is dissolved in 2 mL methanol, and 2 mL methylamine (33% in ethanol) are added. The reaction mixture is stirred at 50° C. over night and all volatiles are removed in vacuo. The product is purified by flash column chromatography (CH2Cl2/MeOH 95:5 to 10:1) yielding 77 mg (0.017 mmol, 94%) of the title compound.

WORKUP

后处理

  1. customall volatiles are removed in vacuo
  2. customThe product is purified by flash column chromatography (CH2Cl2/MeOH 95:5 to 10:1)