Trifluoroacetic acid → HCID 57431183, compound

HRID 1695109Notes

Reaction equation

HRID 1695109 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]([O:13][C@H:14]1[CH2:18][C@@H:17]([C:19]([O:21][CH3:22])=[O:20])[N:16](C)[CH2:15]1)=[O:12].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]([O:13][C@H:14]1[CH2:18][C@@H:17]([C:19]([O:21][CH3:22])=[O:20])[NH:16][CH2:15]1)=[O:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57431182HCID 57431182, compound

Product 1

HCID 57431183HCID 57431183, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 6 (1.45 g, 3.6 mmol) dissolved in DCM (20 ml) was treated with TFA (10 ml) at 0° C. After 2 hr, volatiles are evaporated. The residue is treated with sat. sodium bicarbonate aqueous solution and extracted with DCM. Compound 7 (0.86 g, 79%) is obtained as a pale yellow powder after the evaporation of solvent.

Workup

  1. customvolatiles are evaporated
  2. additionThe residue is treated with sat. sodium bicarbonate aqueous solution
  3. extractionextracted with DCM

Sources & evidence

ORD record
ord-783df84350eb45578f66d572027dfb72
Source dataset
uspto-grants-2012_04
Patent number
US08163693B2

Reaction notes

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