Trifluoroacetic acid methylene chloride → HCID 57624519, compound

HRID 1695112Notes

Reaction equation

HRID 1695112 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]([O:13][C@H:14]1[CH2:18][C@@H:17]([C:19](=[O:40])[NH:20][C@@H:21]([C:36]([CH3:39])([CH3:38])[CH3:37])[C:22]([NH:24][C@@H:25]([CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[C:26]([NH:28][CH3:29])=[O:27])=[O:23])[N:16](CC)[CH2:15]1)=[O:12].C(Cl)Cl.C(O)(C(F)(F)F)=O>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]([O:13][C@H:14]1[CH2:18][C@@H:17]([C:19](=[O:40])[NH:20][C@@H:21]([C:36]([CH3:38])([CH3:37])[CH3:39])[C:22]([NH:24][C@@H:25]([CH:30]2[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)[C:26]([NH:28][CH3:29])=[O:27])=[O:23])[NH:16][CH2:15]1)=[O:12]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 67276668HCID 67276668, compound

Product 1

HCID 57624519HCID 57624519, compoundYield 111.7%

Procedure

Compound 30 (0.238 g) is treated with DCM-TFA (3 ml-1.5 ml) at 0° C. for 1 h. The volatiles are evaporated to dryness. Compound 31 (crude, 0.253 g) is obtained as white foam for use in the next step.

Workup

  1. customThe volatiles are evaporated to dryness

Sources & evidence

ORD record
ord-a7e535b41ce041beb4655637bebe5186
Source dataset
uspto-grants-2012_04
Patent number
US08163693B2

Reaction notes

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