Trifluoroacetic acid → HCID 11552535, compound

HRID 1695119Notes

Reaction equation

HRID 1695119 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9].C(O)(C(F)(F)F)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])(=[O:9])=[O:28]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

Product 1

HCID 11552535HCID 11552535, compound

Procedure

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

Workup

  1. customThe solvent was removed in vacuo, water
  2. additionwas added
  3. extractionthe mixture was extracted with dichloromethane (three times)
  4. dry with materialThe organic extracts were dried (MgSO4)
  5. customevaporated
  6. customtriturated with ether

Sources & evidence

ORD record
ord-20b12bf97bbc422590f8ba45ee7a1892
Source dataset
uspto-grants-2012_04
Patent number
US08163727B2

Reaction notes

Loading…