反应详情

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

1. customThe solvent was removed in vacuo
2. customthe mixture was azeotroped with toluene
3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)