HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzoic acid → 1-(4-Bromo-2-fluorobenzoyl)-3,3-difluoro-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Reactant | 3,3-Difluoropyrrolidine hydrochloride | HCID 24903482 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(4-Bromo-2-fluorobenzoyl)-3,3-difluoro-pyrrolidine | HCID 68604102 | — |
Reaction Steps
The sub-title compound was prepared by the method of example 18 step a) using 4-bromo-2-fluorobenzoic acid and 3,3-difluoropyrrolidine, hydrochloride salt and triethylamine (2 molar equivalent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163727B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-767dfb2be98f4656a170f86c47e5b197 |
| Source note | uspto-grants-2012_04 |