4-Bromo-2-fluorobenzoic acid → 1-(4-Bromo-2-fluorobenzoyl)-3,3-difluoro-pyrrolidine

HRID 1695150Notes

Reaction equation

HRID 1695150 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.Cl.[F:13][C:14]1([F:19])[CH2:18][CH2:17][NH:16][CH2:15]1>C(N(CC)CC)C>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:16]2[CH2:17][CH2:18][C:14]([F:19])([F:13])[CH2:15]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

4

Reactant 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 249034823,3-Difluoropyrrolidine hydrochloride

Product 1

HCID 686041021-(4-Bromo-2-fluorobenzoyl)-3,3-difluoro-pyrrolidine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The sub-title compound was prepared by the method of example 18 step a) using 4-bromo-2-fluorobenzoic acid and 3,3-difluoropyrrolidine, hydrochloride salt and triethylamine (2 molar equivalent).

Sources & evidence

ORD record
ord-767dfb2be98f4656a170f86c47e5b197
Source dataset
uspto-grants-2012_04
Patent number
US08163727B2

Reaction notes

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