Methyl 2-(trifluoromethyl)benzoate → 3-Oxo-3-[2-(trifluoromethyl)phenyl]propanenitrile

HRID 1695174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695174
[NH2:1][C:2]1[CH:6]=CNN=1.CO[C:9](=[O:20])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([F:19])([F:18])[F:17]>>[O:20]=[C:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([F:17])([F:18])[F:19])[CH2:6][C:2]#[N:1]

Komponenten

3

Edukt 2

HCID 2775578Methyl 2-(trifluoromethyl)benzoateHCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 126308073-Oxo-3-[2-(trifluoromethyl)phenyl]propanenitrileAusbeute 94 %

Versuchsvorschrift

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 2-trifluoromethyl-benzoic acid methyl ester (3.1 g, 14.0 mmol, 1.0 eq). The crude was precipitated from HCl to give the title product as a yellow solid (2.8 g, yield: 94%).

Aufarbeitung

  1. customThe product was prepared
  2. customThe crude was precipitated from HCl

Quellen und Nachweise

ORD-Eintrag
ord-e49952edd5b748abaabcd2b8bb4bf5e7
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163729B2

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