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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695174Generated: October 31, 2026

Methyl 2-(trifluoromethyl)benzoate → 3-Oxo-3-[2-(trifluoromethyl)phenyl]propanenitrile

https://huagongshe.com/reaction/1695174

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-(trifluoromethyl)benzoateHCID 2775578—
ReactantHCID 178418806HCID 178418806—
Product3-Oxo-3-[2-(trifluoromethyl)phenyl]propanenitrileHCID 1263080794%

Reaction Steps

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 2-trifluoromethyl-benzoic acid methyl ester (3.1 g, 14.0 mmol, 1.0 eq). The crude was precipitated from HCl to give the title product as a yellow solid (2.8 g, yield: 94%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08163729B2
Source datasetuspto-grants-2012_04
ORD IDord-e49952edd5b748abaabcd2b8bb4bf5e7
Source noteuspto-grants-2012_04