HCID 17887686, compound → 3-(Difluoromethoxy)-β-oxobenzenepropanenitrile

HRID 1695193Notes

Reaction equation

HRID 1695193 reaction equation
[NH2:1][C:2]1[CH:6]=CNN=1.COC(=O)C1C=CC(OCC2CC2)=C(Cl)C=1.CO[C:25](=[O:36])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH:33]([F:35])[F:34])[CH:27]=1>>[F:35][CH:33]([F:34])[O:32][C:28]1[CH:27]=[C:26]([C:25](=[O:36])[CH2:6][C:2]#[N:1])[CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 17887686HCID 17887686, compoundHCID 67015924HCID 67015924, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 431238303-(Difluoromethoxy)-β-oxobenzenepropanenitrile

Procedure

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1 bis) from 3-difluoromethoxy-benzoic acid methyl ester (1.5 g, 7.4 mmol, 1.0 eq). The crude was precipitated by addition of aqueous HCl to give the product which was used directly for the next step.

Workup

  1. customThe product was prepared
  2. customThe crude was precipitated by addition of aqueous HCl
  3. customto give the product which

Sources & evidence

ORD record
ord-5361f984f3ab4019976042004fa93322
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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