反应详情

温度

60 °C

A suspension of 3-(4-methoxyphenyl)-3-oxopropanenitrile in ethanol was heated to 60° C. Hydrazine hydrate was added dropwise over a minimum of 30 min at 60° C. The resulting solution was held at 60° C. until reaction completion, generally 15-18 hr. The reaction mixture was quenched with water. Ethanol was removed by distillation to about 5 volumes. The product was isolated by filtration, washed with water and dried in a vacuum oven. The yield was 88-95%.

1. customThe resulting solution was held at 60° C. until reaction completion, generally 15-18 hr
2. customThe reaction mixture was quenched with water
3. customEthanol was removed by distillation to about 5 volumes
4. customThe product was isolated by filtration
5. washwashed with water
6. customdried in a vacuum oven