Hydrazine hydrate (1:1) → HCID 178507318, Verbindung

HRID 1695231Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695231
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=O)[CH2:11][C:12]#[N:13])=[CH:2]1.O.[NH2:16][NH2:17]>CCO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]2[CH:11]=[C:12]([NH2:13])[NH:16][N:17]=2)=[CH:2]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 24535683-(Cyanoacetyl)indole

Produkt 1

HCID 178507318HCID 178507318, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 3-(1H-indol-3-yl)-3-oxo-propionitrile (6.4 g, 34.7 mmol, 1.0 eq), in absolute EtOH (40 mL), hydrazine monohydrate (5.0 mL, 104.1 mmol, 3.0 eq) was added and the reaction was heated at reflux for 24 hours. The reaction mixture was allowed to cool to room temperature; the solid was filtered and washed with Et2O/EtOAc 10/1 to give 3.0 g of title product (yield 74%).

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 24 hours
  3. filtrationthe solid was filtered
  4. washwashed with Et2O/EtOAc 10/1

Quellen und Nachweise

ORD-Eintrag
ord-a6961d018d8f454180125e91acd4cf60
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163729B2

Notizen zur Reaktion

Wird geladen…