3-(1-Ethyl-1H-indol-3-yl)-3-oxo-propionitrile → HCID 178462497, compound

HRID 1695238Notes

Reaction equation

HRID 1695238 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[CH2:7]([N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](C(=O)CC#N)=[CH:10]1)[CH3:8]>>[CH2:7]([N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:5]2[CH:6]=[C:2]([NH2:1])[NH:3][N:4]=2)=[CH:10]1)[CH3:8]

Participants

3

Reactant 2

HCID 671880253-(1-Ethyl-1H-indol-3-yl)-3-oxo-propionitrileHCID 178418806HCID 178418806, compound

Product 1

HCID 178462497HCID 178462497, compoundYield 70%

Procedure

The product was prepared according to general procedure for aminopyrazole synthesis (route A2) starting from 3-(1-ethyl-1H-indol-3-yl)-3-oxo-propionitrile (820 mg, 3.87 mmol, 1.0 eq). The solvent was removed under reduced pressure; the solid residue was washed with EtOH to obtain the title product (612 mg, 70% yield).

Workup

  1. customThe product was prepared
  2. customThe solvent was removed under reduced pressure
  3. washthe solid residue was washed with EtOH

Sources & evidence

ORD record
ord-8ad9340eb697481390c7c7aeaf98867b
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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