Methyl 4-(difluoromethoxy)benzoate → 3-[4-(difluoromethoxy)phenyl]-3-oxopropanenitrile

HRID 1695243Notes

Reaction equation

HRID 1695243 reaction equation
[NH2:1][C:2]1[CH:6]=CNN=1.CO[C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH:17]([F:19])[F:18])=[CH:12][CH:11]=1>>[F:19][CH:17]([F:18])[O:16][C:13]1[CH:12]=[CH:11][C:10]([C:9](=[O:20])[CH2:6][C:2]#[N:1])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7017143Methyl 4-(difluoromethoxy)benzoateHCID 178418806HCID 178418806, compound

Product 1

HCID 246973133-[4-(difluoromethoxy)phenyl]-3-oxopropanenitrileYield 90%

Procedure

The product was prepared according to the general procedure for aminopyrazole synthesis from 872.0 mg (4.3 mmol, 1.0 eq) of 4-difluoromethoxy-benzoic acid methyl ester (route A1bis). 818.5 mg of the title product (yield 90%) were used directly for the following step.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-234edfb8b2504d01acad84db89949837
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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