Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695243Generated: October 30, 2026

Methyl 4-(difluoromethoxy)benzoate → 3-[4-(difluoromethoxy)phenyl]-3-oxopropanenitrile

https://huagongshe.com/reaction/1695243

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-(difluoromethoxy)benzoateHCID 7017143—
ReactantHCID 178418806HCID 178418806—
Product3-[4-(difluoromethoxy)phenyl]-3-oxopropanenitrileHCID 2469731390%

Reaction Steps

The product was prepared according to the general procedure for aminopyrazole synthesis from 872.0 mg (4.3 mmol, 1.0 eq) of 4-difluoromethoxy-benzoic acid methyl ester (route A1bis). 818.5 mg of the title product (yield 90%) were used directly for the following step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08163729B2
Source datasetuspto-grants-2012_04
ORD IDord-234edfb8b2504d01acad84db89949837
Source noteuspto-grants-2012_04