Hydrogen Bromide → HCID 21251747, compound

HRID 1695249Notes

Reaction equation

HRID 1695249 reaction equation
Br.C[O:3][C:4](=[O:15])[C:5]([CH2:11][CH2:12][CH2:13][Br:14])(C)[C:6](OC)=O.[OH-].[Na+]>>[Br:14][CH2:13][CH2:12][CH2:11][CH:5]([CH3:6])[C:4]([OH:15])=[O:3]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 57523451HCID 57523451, compound

Product 1

HCID 21251747HCID 21251747, compoundYield 62%

Conditions

Temperature
120 °C

Procedure

HBr aq 48% (10 mL, 88.4 mmol) was added at room temperature to 2-(3-bromo-propyl)-2-methyl-malonic acid dimethyl ester (1.80 g, 6.74 mmol) and the mixture was stirred and heated at 120° C. for 24 hours. After cooling to room temperature, NaOH solution was added to reach pH 3 and the product was extracted using a mixture DCM:MeOH 95:5. The obtained crude (0.81 g, 62% yield) was clean enough to be used without further purification.

Workup

  1. temperatureAfter cooling to room temperature
  2. extractionthe product was extracted
  3. customThe obtained crude (0.81 g, 62% yield)
  4. customto be used without further purification

Sources & evidence

ORD record
ord-8124b85a90de434595ec07fd7324f6f0
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

Loading…