反应详情

To a suspension of 4-pyrrolidin-l-yl-pentanoic acid methyl ester (2.0 g, 10.0 mmol) in water (20 mL), NaOH (0.8 g, 20.0 mmol, 2.0 eq) was added and the mixture was heated at reflux for 10 hours. The reaction was then allowed to cool to room temperature, the pH was adjusted to 3 with HCl 37% and the mixture was concentrated under reduced pressure. The residue was treated with EtOH, the sodium chloride precipitated was filtered off and the solvent was evaporated under reduced pressure, affording 1.7 g of the title compound as white solid (99% yield).

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureat reflux for 10 hours
4. concentrationthe mixture was concentrated under reduced pressure
5. additionThe residue was treated with EtOH
6. customthe sodium chloride precipitated
7. filtrationwas filtered off
8. customthe solvent was evaporated under reduced pressure