Ammonia → HCID 49792921, compound

HRID 1695334Notes

Reaction equation

HRID 1695334 reaction equation
C[O:2][C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=O.[NH3:24]>CO>[CH3:17][C:16]1[O:15][N:14]=[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]=1[CH2:11][O:10][C:8]1[CH:9]=[C:5]([C:3]([NH2:24])=[O:2])[NH:6][N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66643884HCID 66643884, compound

Product 1

HCID 49792921HCID 49792921, compoundYield 16%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described for example 6, 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.32 mmol) was converted, using ammonia in methanol instead of ethanolamine, to the title compound (15 mg, 16%), which was obtained as a white solid. MS: m/e=299.4 [M+H]+.

Sources & evidence

ORD record
ord-ac0caea75ebe48008e5fef737f6c2ef0
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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