1,1-Dimethylhydrazine → HCID 59568413, compound

HRID 1695371Notes

Reaction equation

HRID 1695371 reaction equation
CO[C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4].[CH3:22][N:23]([CH3:25])[NH2:24]>>[CH3:22][N:23]([CH3:25])[NH:24][C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4]

Participants

3

Reactant 2

HCID 59761,1-DimethylhydrazineHCID 66643879HCID 66643879, compound

Product 1

HCID 59568413HCID 59568413, compoundYield 59%

Procedure

As described for example 26d, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.34 mmol) was converted, using N,N-dimethylhydrazine instead of 4-aminotetrahydropyran, to the title compound (65 mg, 59%) which was obtained as a colorless oil. MS: m/e=322.3 [M+H]+.

Sources & evidence

ORD record
ord-4924df21db5b4316b68c0fd25d4686c2
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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