1-Aminopiperidine → HCID 59568393, compound

HRID 1695375Notes

Reaction equation

CO[C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4].[NH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[N:23]1([NH:22][C:3]([C:5]2[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]3[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=3[CH3:17])[CH:9]=2)=[O:4])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

Reactant 2

HCID 166581-Aminopiperidine

HCID 66643879HCID 66643879, compound

Product 1

HCID 59568393HCID 59568393, compoundYield 85%

Procedure

As described for example 26d, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (218 mg, 0.74 mmol) was converted, using 1-aminopiperidine instead of 4-aminotetrahydropyran, to the title compound (228 mg, 85%) which was obtained as a colorless oil. MS: m/e=362.2 [M+H]+.

Sources & evidence

ORD record: ord-06735ba4aaee43ae92ab5033e1debcdf
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163728B2

Reaction notes

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