3-Amino-1,1,1-trifluoropropan-2-ol → HCID 59568417, compound

HRID 1695398Notes

Reaction equation

HRID 1695398 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH2:25][CH2:26][CH:27]([OH:32])[C:28]([F:31])([F:30])[F:29]>>[F:29][C:28]([F:31])([F:30])[CH:27]([OH:32])[CH2:26][NH:25][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:23]

Participants

3

Reactant 2

HCID 4189653-Amino-1,1,1-trifluoropropan-2-olHCID 66643617HCID 66643617, compound

Product 1

HCID 59568417HCID 59568417, compoundYield 47%

Procedure

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.3 mmol) was converted, using rac-3-amino-1,1,1-trifluoropropan-2-ol instead of 2-amino-2-methyl-1-propanol, to the title compound (63 mg, 47%) which was obtained as a colorless gum. MS: m/e=443.2 [M+H]+.

Sources & evidence

ORD record
ord-125e8e9081d349978db98ec4241114c0
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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