3-Amino-1,1,1-trifluoropropan-2-ol → HCID 59568417, compound

Participants

Reaction Steps

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.3 mmol) was converted, using rac-3-amino-1,1,1-trifluoropropan-2-ol instead of 2-amino-2-methyl-1-propanol, to the title compound (63 mg, 47%) which was obtained as a colorless gum. MS: m/e=443.2 [M+H]+.

Provenance & Evidence