1-Propanol, 3-amino-2,2-dimethyl- → HCID 59568390, compound

HRID 1695403Notes

Reaction equation

HRID 1695403 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH2:25][CH2:26][C:27]([CH3:31])([CH3:30])[CH2:28][OH:29]>>[OH:29][CH2:28][C:27]([CH3:31])([CH3:30])[CH2:26][NH:25][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:22]

Participants

3

Reactant 2

HCID 1173261-Propanol, 3-amino-2,2-dimethyl-HCID 66643617HCID 66643617, compound

Product 1

HCID 59568390HCID 59568390, compoundYield 70%

Procedure

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.3 mmol) was converted, using 3-amino-2,2-dimethyl-1-propanol instead of 2-amino-2-methyl-1-propanol, to the title compound (88 mg, 70%) which was obtained as a white solid. MS: m/e=417.2 [M+H]+.

Sources & evidence

ORD record
ord-84a5f60e3ac7441b983de5645be1c6a0
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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