2-Aminopropanol → HCID 66643963, compound

HRID 1695408Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:25][CH:26]([NH2:29])[CH2:27][OH:28]>>[OH:28][CH2:27][CH:26]([NH:29][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:22])[CH3:25]

Participants

Reactant 2

HCID 51262-Aminopropanol

HCID 66643617HCID 66643617, compound

Product 1

HCID 66643963HCID 66643963, compoundYield 66%

Procedure

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (200 mg, 0.6 mmol) was converted, using DL-2-amino-1-propanol instead of 2-amino-2-methyl-1-propanol, to the title compound (155 mg, 66%) which was obtained as a white solid. MS: m/e=389.1 [M+H]+.

Sources & evidence

ORD record: ord-1393f2dff72b46379bc17525032e2410
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163728B2

Reaction notes

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