反应详情

To a solution of 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester (700 mg, 2.1 mmol) in DMF (10 mL) at room temperature was added cesium carbonate (686 mg, 2.1 mmol) and methyliodide (299 mg, 0.13 mL, 2.1 mmol) and the resulting mixture stirred for 30 min. The resulting mixture was then evaporated and extracted with ethyl acetate and water. The organic extract was then washed with water, brine, dried over sodium sulfate and evaporated. Purification by chromatography (silica, heptane:ethyl acetate=4:1 to 2:3) afforded the title compound (354 mg, 49%) which was obtained as a white solid.

1. customThe resulting mixture was then evaporated
2. extractionextracted with ethyl acetate and water
3. extractionThe organic extract
4. washwas then washed with water, brine
5. dry with materialdried over sodium sulfate
6. customevaporated
7. customPurification by chromatography (silica, heptane:ethyl acetate=4:1 to 2:3)