反应详情

As described for example 81c, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (73 mg, 0.21 mmol) was converted, using 4-aminotetrahydropyran instead of morpholine, to the title compound (32 mg, 37%) which was obtained as a white solid. MS: m/e=416.2 [M+H]+.