反应详情

As described for example 112h, 5-(3-butyl-5-hydroxymethyl-isoxazol-4-ylmethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid (50 mg, 0.16 mmol) was converted, using cyclobutylamine instead of 2,2,2-trifluoroethylamine HCl, to the title compound (45 mg, 78%) which was obtained as a colorless oil. MS: m/e=363.3 [M+H]+.