Ammonia → HCID 49793043, compound

HRID 1695476Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH3:25]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:21]([NH2:25])=[O:23])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 66643882HCID 66643882, compound

Product 1

HCID 49793043HCID 49793043, compoundYield 60%

Procedure

As described for example 122, 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using ammonia instead of isopropylamine, to the title compound (19 mg, 60%) which was obtained as a white solid. MS: m/e=327.2 [M+H]+.

Sources & evidence

ORD record: ord-e0118b18d4e1490694a02d6fe29e580b
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163728B2

Reaction notes

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