Ammonia → HCID 59568427, compound

HRID 1695490Notes

Reaction equation

HRID 1695490 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH3:25]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:16]=[C:17]([C:21]([NH2:25])=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 66643816HCID 66643816, compound

Product 1

HCID 59568427HCID 59568427, compoundYield 20%

Procedure

As described for example 144, 5-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using ammonia instead of 2-hydroxy-2-methylpropylamine, to the title compound (12 mg, 20%) which was obtained as an off white solid. MS: m/e=330.4 [M+H]+.

Sources & evidence

ORD record
ord-f9b5d03d318b420797a5b3914416a98d
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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