Ammonia → HCID 49793112, compound

HRID 1695498Notes

Reaction equation

HRID 1695498 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:16]=[C:17]([C:20](O)=[O:21])[NH:18][N:19]=3)=[C:11]([CH3:23])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH3:24]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:16]=[C:17]([C:20]([NH2:24])=[O:21])[NH:18][N:19]=3)=[C:11]([CH3:23])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 666437645-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-2H-pyrazole-3-carboxylic acid

Product 1

HCID 49793112HCID 49793112, compoundYield 29%

Procedure

As described for example 152, 5-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-2H-pyrazole-3-carboxylic acid was converted, using ammonia instead of 2-hydroxy-2-methylpropylamine, to the title compound (17 mg, 29%) which was obtained as an off white solid. MS: m/e=316.4 [M+H]+.

Sources & evidence

ORD record
ord-bf4f818dd2844c898de557c29e5d79df
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

Loading…