3-Amino-3-methyloxetane → HCID 59568402, compound

HRID 1695506Notes

Reaction equation

HRID 1695506 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][C:4]([NH:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])=[N:3]1.[CH3:24][C:25]1([NH2:29])[CH2:28][O:27][CH2:26]1>>[CH3:1][N:2]1[C:6]([C:7]([NH:29][C:25]2([CH3:24])[CH2:28][O:27][CH2:26]2)=[O:9])=[CH:5][C:4]([NH:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])=[N:3]1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 66646518HCID 66646518, compound

Product 1

HCID 59568402HCID 59568402, compoundYield 70%

Procedure

As described for example 160c, 1-methyl-3-((5-methyl-3-(pyridin-2-yl)isoxazol-4-yl)methylamino)-1H-pyrazole-5-carboxylic acid (80 mg, 255 μmol) was converted, using 3-methyl-3-oxetanamine instead of isopropylamine, to the title compound (68 mg, 70%) which was obtained as a white solid. MS: m/e=383.3 [M+H]+.

Sources & evidence

ORD record
ord-e2118662f0554a43bde5afe9438f0b5a
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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