Cyclopropylamine → HCID 59568394, compound

HRID 1695508Notes

Reaction equation

HRID 1695508 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:19]=[C:18]([C:20]([OH:22])=O)[N:17]([CH3:23])[N:16]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[N:6][CH:7]=1.[CH:25]1([NH2:28])[CH2:27][CH2:26]1>>[CH:25]1([NH:28][C:20]([C:18]2[N:17]([CH3:23])[N:16]=[C:15]([NH:14][CH2:13][C:12]3[C:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][N:6]=4)=[N:9][O:10][C:11]=3[CH3:24])[CH:19]=2)=[O:22])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 66646190HCID 66646190, compound

Product 1

HCID 59568394HCID 59568394, compoundYield 76%

Procedure

As described for example 163c, 3-((3-(5-fluoropyridin-2-yl)-5-methylisoxazol-4-yl)methylamino)-1-methyl-1H-pyrazole-5-carboxylic acid (92 mg, 0.28 mol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (78 mg, 76%) which was obtained as a white solid. MS: m/e=371.3 [M+H]+.

Sources & evidence

ORD record
ord-085dec01bb1240079814e832854d0abc
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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