Potassium Carbonate → 2-(1-(2-Nitrophenyl)ethylamino)acetonitrile

HRID 1695515Notes

Reaction equation

HRID 1695515 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].[C:12]([O-])([O-])=O.[K+].[K+].C[CH:19](Br)[C:20]#[N:21]>C(#N)C>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]([NH:7][CH2:19][C:20]#[N:21])[CH3:12])([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1405382-BromopropionitrileHCID 423893(2-Nitrophenyl)methanamine

Product 1

HCID 866252282-(1-(2-Nitrophenyl)ethylamino)acetonitrile

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
65 °C

Procedure

2-Nitrobenzylamine (513 mg, 3.37 mmol) was added to an acetonitrile (40 mL) containing K2CO3 (932 mg, 6.74 mmol) and 2-bromopropanitrile (677 mg, 5.06 mmol) under a nitrogen atmosphere. The reaction mixture was heated to 65° C. for 14 hours. The product (18) was used without purification or concentration in the next step.

Workup

  1. customThe product (18) was used without purification or concentration in the next step

Sources & evidence

ORD record
ord-8046259b90de42408c5cb640d8abaafc
Source dataset
uspto-grants-2012_04
Patent number
US08163738B2

Reaction notes

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