HCID 11805402, compound → HCID 544380, compound

HRID 1695523Notes

Reaction equation

HRID 1695523 reaction equation
C([O:3][C:4]([CH:6]1[CH:13]2[N:9]([CH2:10][CH2:11][CH2:12]2)[CH2:8][CH2:7]1)=O)C>C1COCC1.C(OCC)C.O>[CH:6]1([CH2:4][OH:3])[CH:13]2[N:9]([CH2:10][CH2:11][CH2:12]2)[CH2:8][CH2:7]1

Participants

5

Reactant 1

HCID 11805402HCID 11805402, compound

Product 1

HCID 544380HCID 544380, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

Lithiumaluminumhydride (0.3 g) was added to a solution of hexahydropyrrolizine-1-carboxylic acid ethyl ester (0.97 g) in THF (3 ml). After 12 hours, the reaction mixture was diluted with diethyl ether and hydrolyzed by cautious addition of water (0.7 ml). The resulting precipitate was filtered off and the filtrate was concentrated. The product with the molecular weight of 141.21 (C8H15NO); MS (ESI): 142 (M+H+) was obtained in this way.

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. concentrationthe filtrate was concentrated
  3. customMS (ESI): 142 (M+H+) was obtained in this way

Sources & evidence

ORD record
ord-6ceb7dd6874140a6b613ce5090379d04
Source dataset
uspto-grants-2012_04
Patent number
US08163741B2

Reaction notes

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