反应详情

To a solution of methyl-6-chloro-2-fluoro-3-formylbenzoate (930 mg, 4294 μmol) in ethanol (14.5 ml) at RT was added hydroxylamine (50 wt. % aqueous solution) (1316 μl, 21469 μmol) and the solution was stirred for 16 hrs. The volatiles were removed by rotovap, the residue was diluted with water which caused a solid to precipitate. The solid was collected by filtration and washed with water and dried in vacuo to give the title compound as an off-white solid.

1. customThe volatiles were removed by rotovap
2. additionthe residue was diluted with water which
3. customto precipitate
4. filtrationThe solid was collected by filtration
5. washwashed with water
6. customdried in vacuo