1-Methylpiperazine → HCID 178488345, compound

HRID 1695585Notes

Reaction equation

HRID 1695585 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:27]=[CH:26][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:19]4[C:20]([O:24][CH3:25])=[CH:21][CH:22]=[CH:23][C:18]=4[O:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH3:25][O:24][C:20]1[C:19]2[CH:15]([NH:14][C:11]3[O:12][CH2:13][C:8]4[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:32]5[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][CH2:31]5)[CH:27]=[CH:26][C:9]=4[N:10]=3)[CH2:16][O:17][C:18]=2[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178488343HCID 178488343, compound

Product 1

HCID 178488345HCID 178488345, compoundYield 79.3%

Procedure

Prepared from rac-2-chloro-N-[2-(4-methoxy-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 8) (370 mg, 0.95 mmol) and 1-methylpiperazine (2.12 ml, 19.08 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (340 mg, 79%), MS (ISP) m/e=452.3 [(M+H)+].

Sources & evidence

ORD record
ord-c787d6e7f867458c9639f46d62b42c48
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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