7-Methoxy-2,3-dihydro-1H-inden-1-amine → HCID 178488350, compound

HRID 1695587Notes

Reaction equation

HRID 1695587 reaction equation
C([Si]([O:8][CH2:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1[N:19]=[C:20]=S)(C)C)(C)(C)C.[CH3:22][O:23][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:32]=1[CH:31]([NH2:33])[CH2:30][CH2:29]2>>[CH3:22][O:23][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:32]=1[CH:31]([NH:33][C:20]1[O:8][CH2:9][C:10]3[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=3[N:19]=1)[CH2:30][CH2:29]2

Participants

3

Reactant 2

HCID 186198817-Methoxy-2,3-dihydro-1H-inden-1-amineHCID 46855450tert-Butyl-(2-isothiocyanato-5-nitro-benzyloxy)-dimethyl-silane

Product 1

HCID 178488350HCID 178488350, compoundYield 73.4%

Procedure

Prepared from tert-butyl-(2-isothiocyanato-5-nitro-benzyloxy)-dimethyl-silane (Example C1) (3.89 g, 12.0 mmol; HPLC: 4.446 min) and the above described rac-7-methoxy-indan-1-ylamine (1.96 g, 12.0 mmol; HPLC 0.4 min) according to the procedure described for Example 1. Obtained the title compound as a yellow solid (2.99 g, 73%; HPLC 1.683 min), MS (ISP) m/e=340.1 [(M+H)+].

Sources & evidence

ORD record
ord-6e92ab60f08b4b1ca98fe91f34f12a20
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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