Methoxyacetyl chloride → HCID 178496376, compound

HRID 1695593Notes

Reaction equation

HRID 1695593 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH:11][C:12]1[O:13][CH2:14][C:15]3[CH:21]=[C:20]([NH2:22])[CH:19]=[CH:18][C:16]=3[N:17]=1)[CH2:6][CH2:5]2.[CH3:23][O:24][CH2:25][C:26](Cl)=[O:27]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH:11][C:12]1[O:13][CH2:14][C:15]3[CH:21]=[C:20]([NH:22][C:26](=[O:27])[CH2:25][O:24][CH3:23])[CH:19]=[CH:18][C:16]=3[N:17]=1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 96623Methoxyacetyl chlorideHCID 178507248HCID 178507248, compound

Product 1

HCID 178496376HCID 178496376, compoundYield 40.3%

Procedure

Prepared from rac-N2-(5-fluoro-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 11) (100 mg, 0.336 mmol) and methoxyacetyl chloride (34 ul, 0.370 mmol) according to the procedure described for Example 17. Obtained the title compound as a white solid (50 mg, 40%), MS (ISP) m/e=370.2 [(M+H)+].

Sources & evidence

ORD record
ord-bf058083524d4be096025aa178537969
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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