1-Methylpiperazine → HCID 178489488, compound

HRID 1695599Notes

Reaction equation

HRID 1695599 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH3:23])[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:23][O:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH2:15][NH:14][C:11]1[O:12][CH2:13][C:8]2[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:30]3[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]3)[CH:25]=[CH:24][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178489487HCID 178489487, compound

Product 1

HCID 178489488HCID 178489488, compoundYield 225.1%

Procedure

Prepared from the above described 2-chloro-N-[2-(2-methoxy-benzylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (50 mg, 0.129 mmol, HPLC 0.889 min 81%) and N-methylpiperazine (900 ul, 8 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (123 mg, 73%, HPLC 0.531 min 100%), MS (ISP) m/e=424.4 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-01c4cc77e13b45938090b7812f2d9d7d
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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