1-Isopropylpiperazine → HCID 178489489, compound

HRID 1695601Notes

Reaction equation

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH3:23])[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH:26]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)([CH3:28])[CH3:27]>>[CH:26]([N:29]1[CH2:34][CH2:33][N:32]([CH2:2][C:3]([NH:5][C:6]2[CH:25]=[CH:24][C:9]3[N:10]=[C:11]([NH:14][CH2:15][C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[O:22][CH3:23])[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH2:31][CH2:30]1)([CH3:28])[CH3:27]

Participants

Reactant 2

HCID 780131-Isopropylpiperazine

HCID 178489487HCID 178489487, compound

Product 1

HCID 178489489HCID 178489489, compoundYield 257.5%

Procedure

Prepared from 2-chloro-N-[2-(2-methoxy-benzylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 26 step A) (50 mg, 0.129 mmol, HPLC 0.889 min 81%) and N-isopropylpiperazine (1 ml, 8 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (150 mg, 72%, HPLC 0.492 min 87%), MS (ISP) m/e=452.3 [(M+H)+].

Sources & evidence

ORD record: ord-229feb39c5dd41609890af75b0a4b4b4
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163740B2

Reaction notes

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