1-Aminotetralin, (R)- → HCID 178526447, compound

HRID 1695602Notes

Reaction equation

HRID 1695602 reaction equation
C([Si]([O:8][CH2:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1[N:19]=[C:20]=S)(C)C)(C)(C)C.[NH2:22][C@H:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH2:24]1>>[N+:16]([C:14]1[CH:13]=[CH:12][C:11]2[N:19]=[C:20]([NH:22][C@H:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:26][CH2:25][CH2:24]3)[O:8][CH2:9][C:10]=2[CH:15]=1)([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 70580721-Aminotetralin, (R)-HCID 46855450tert-Butyl-(2-isothiocyanato-5-nitro-benzyloxy)-dimethyl-silane

Product 1

HCID 178526447HCID 178526447, compoundYield 80.2%

Procedure

Prepared from tert-butyl-(2-isothiocyanato-5-nitro-benzyloxy)-dimethyl-silane (Example C1) (3.894 g, 12.0 mmol; HPLC: 4.446 min) and (R)-1-aminotetralin (CAS 21966-60-9) (1.767 g, 12.0 mmol; HPLC: 0.390 min) according to the procedure described for Example 1. Obtained the title compound as a yellow foam (3.11 g, 80%, HPLC 2.211 min), MS (ISP) m/e=324.2 [(M+H)+].

Sources & evidence

ORD record
ord-07f200482a57418c9c19cdb23f166a82
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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