1-Methylpiperazine → HCID 178480918, compound

Participants

Reaction Steps

Prepared from the above described 2-chloro-N-{2-[(R)-(1,2,3,4-tetrahydro-naphthalen-1-yl)amino]-4H-benzo[d][1,3]oxazin-6-yl}-acetamide (150 mg, 0.406 mmol, HPLC 1.185 min) and N-methylpiperazine (901 ul, 8.1 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (176 mg, 100%, HPLC 0.503 min), MS (ISP) m/e=434.4 [(M+H)+].

Provenance & Evidence