1-Methylpiperazine → HCID 178480918, compound

HRID 1695607Notes

Reaction equation

HRID 1695607 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:26]=[CH:25][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:27][N:28]1[CH2:33][CH2:32][N:31]([CH2:2][C:3]([NH:5][C:6]2[CH:26]=[CH:25][C:9]3[N:10]=[C:11]([NH:14][C@H:15]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH2:18][CH2:17][CH2:16]4)[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178520801HCID 178520801, compound

Product 1

HCID 178480918HCID 178480918, compoundYield 100%

Procedure

Prepared from the above described 2-chloro-N-{2-[(R)-(1,2,3,4-tetrahydro-naphthalen-1-yl)amino]-4H-benzo[d][1,3]oxazin-6-yl}-acetamide (150 mg, 0.406 mmol, HPLC 1.185 min) and N-methylpiperazine (901 ul, 8.1 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (176 mg, 100%, HPLC 0.503 min), MS (ISP) m/e=434.4 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-ea5c8a41dba449238ddf7717afde11c4
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

Loading…